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Open discussions on papers, inventions, patents and technological breakthroughs. Scientists, engineers and AI experts debate what shapes the future.

Paper · Nature·2 h ago

AlphaFold 3: predicting protein-ligand complexes with crystallographic precision

Dr. Elena Voronova · MIT

If RMSD < 2Å holds steadily on new targets, this is a turning point for drug design. But validation on GPCR is still shaky…

47 312 4,820
Invention · Patent US20260112233·5 h ago

Solid-state batteries with sulfide electrolyte — Toyota / Idemitsu filing

Prof. Henrik Lund · DTU

1200 cycles at 80% capacity — that is on the edge of commercialization. The only question is the cost of the Li2S precursor…

23 188 2,104
Preprint · arXiv 2511.04421·yesterday

Room-temperature superconductivity in modified LK-99: third independent replication

Anonymous

Folks, drop the hype. Meissner effect is not a proof. We need a direct transport measurement at zero resistance.

412 891 28,430
Discussion·yesterday

Why does the EU AI Act kill open-source foundation models?

Marc Dubois · INRIA

Compute threshold of 10^25 FLOPs is a political decision, not a scientific one. Llama 4 formally avoids it, in practice it doesn't.

156 401 11,200
Invention · DOE / ARPA-E·2 days ago

Direct Air Capture at $87/ton — Heirloom pilot in California

Sarah Klein · ETH Zürich

If you do the LCA honestly, including calcination energy, the real number is ~$140. But the trend is right.

34 220 3,560
Paper · Science·3 days ago

CRISPR-Cas13 for in-vivo RNA editing: first clinical data

Dr. Yuki Tanaka · RIKEN

Off-target in the liver is still 0.3% — acceptable for genetic disease, not for oncology.

78 540 8,920
Discussion·4 days ago

Quantum advantage from IBM Heron r3 — real or marketing?

Prof. Alessandro Rossi · ETH

156 qubits with T1 ~ 250µs is serious. But a classical simulator on A100 still beats their benchmark.

92 274 6,010
Invention·a week ago

Northvolt Ett: first European 60 GWh gigafactory — year-end results

Lars Andersson · Chalmers

Yield on cathode active material is up to 94%. The main problem is nickel supply.

28 165 2,890